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KMID : 0984720060380050290
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Infection and Chemotherapy
2006 Volume.38 No. 5 p.290 ~ p.295
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A Case of Disseminated Scedosporium apiospermum Infection in a Liver Transplant Patient
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Park Hyun-Gu
Choi Seong-Ho
Kang Ho-Suk
Song Ju-Hyung
Jung Ji-Hoon
So Min-Wook
Choi Sang-Ho
Kim Yang-Soo
Woo Jun-Hee
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Abstract
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Sedosporium apiospermum is a saprophytic fungus commonly found in soil and polluted water. This
organism is known as a cause of mycetoma, which may occur in immunocompetent hosts following
trauma. However, in immunocompromised patients, S. apiospermum can also cause life-threatening
invasive disease, including central nervous system infection or disseminated infection. We report a fatal
case of disseminated S. apiospermum infection in a 46-year-old woman after liver transplantation. Eight
days postoperatively, she developed pneumonia, followed by altered mentality in the 15 days. A head
CT demonstrated multiple brain abscesses. Sputum and stereotactic-aspirated brain abscess culture
yielded S. apiospermum. Despite treatment with voriconazole, the patient died of intracranial
hemorrhage.
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KEYWORD
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Scedosporium apiospermum, Liver transplantation, Voriconazole
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